Megamind vs. the Doom Syndicate is a 2024 American animated superhero comedy film directed by Eric Fogel from a screenplay by Alan Schoolcraft and Brent Simons. It is the second installment of the Megamind film series and a sequel to Megamind (2010), which also serves as the pilot for the television series, Megamind Rules!. The film stars Keith Ferguson as Megamind, who clashes with his former supervillain team who plans to launch Metro City to the moon. Laura Post and Josh Brener also star as Roxanne Ritchie and Ol' Chum (formerly known as Minion) respectively, with Maya Aoki Tuttle, Emily Tunon, Talon Warburton, Scott Adsit, Chris Sullivan, Tony Hale, Jeanine Mason, and Adam Lambert joining.
Unlike its predecessor, Megamind vs. the Doom Syndicate was produced by DreamWorks Animation Television and was released on Peacock on March 1, 2024. It was panned by critics and audiences, with many deeming it inferior to its precursor.