Romance[]
Lucy Wilde[]

Gru marrying Lucy.
Gru first met Lucy in Despicable Me 2.
Family[]
Marlena Gru[]
Robert Gru[]
Dru Gru[]
Margo, Edith and Agnes[]
Gru, Jr.[]
Friends[]
Dr. Nefario[]
Gru first met Dr. Nefario when he was 8 years old at the Villain Con,
The Minions[]
Kevin, Stuart and Bob[]
Mel[]
Gru is shown to have a close bond and friendship with Mel who proves himself as leader of the minions.
Otto[]
Wild Knuckles[]
When Gru was a child and a big fan of the Vicious 6,
Fred McDade[]
Fred is Gru's next-door neighbor.
Silas Ramsbottom[]
Poppy Prescott[]
Enemies[]
Vector[]

Gru meeting Vector.
Vector was one of Gru's villainous rivals. After meeting him at the Bank of Evil, Gru seem to be very annoyed when Vector introduces himself to him, in fact bothering him while looking over his blueprints about stealing the moon. After learning that Vector was the one who stole a pyramid in Egypt, and was one of Mr. Perkins favorite and younger villains, Gru was angered and freezes Vector's head, driving the young villain to steal the shrank ray from Gru, whom he stole earlier (unaware that is was in the order from Mr. Perkins who asked Vector to steal it instead).
When Gru steals the shrink ray from the top secret research facility in East Asia, Vector have followed him, and stole it from him.
Mr. Perkins[]
Miss Hattie[]
El Macho[]
When Gru first met El Macho at the shop "Bake My Days", whom was first present as Eduardo Perez, Gru find him very annoyed at first, until learning that he reminds him of an old villain known as El Macho, and believes that Eduardo Perez was him.
El Pollito[]
After breaking into El Macho's restaurant along with Lucy…
Antonio Perez[]
Scarlet Overkill[]
Balthazar Bratt[]

Gru facing Bratt.
Bratt is Gru's archenemy.
Vicious 6[]
Maxime Le Mal[]

Gru encountering Maxime Le Mal.